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Note that topiramate may reduce the efficacy of combined hormonal contraceptives (particularly those containing ethinylestradiol at lower doses)

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However, no studies of head-to-head trials on the treatment of MASLD with phentermine and topiramate vs semaglutide have been published, and there have been no clinical trials to date that have directly compared the anti-obesity medications in the adolescent population

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The more aggressive forms of prostate cancer are more frequent in obese men [35,36]