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Further research is needed to optimize treatment protocols, develop more personalized approaches, and explore novel combination therapies

A Some people with T2D may want to stop taking metformin due to the side effects, a wish to manage the condition through lifestyle changes, or to avoid the long-term use of a medication

Plant J 37:645653 Saito N, Robert M, Kochi H, Matsuo G, Kakazu Y, Soga T, Tomita M (2009) Metabolite profiling reveals YihU as a novel hydroxybutyrate dehydrogenase for alternative succinic semialdehyde metabolism in Escherichia coli

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