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As mentioned above, initiation of the coagulation process is responsible for the production of FXIIa, which activates the intrinsic coagulation pathway, leading to thrombin formation

Unlike kinases where multiple inhibitors have been developed and tested in clinical trials the most commonly used palmitoylation inhibitor 2-BP cannot be used in the clinic due to its toxicity with off-target effects including interference with fatty acid metabolism (104)

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Omnivorous diets have been found to provide 23 to 135 mg/day of L-carnitine for an average 70 kg person, while strict vegetarian diets may provide as little as 1 mg/day for a 70 kg person (8)

Makker K, Agarwal A, Sharma R