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The drug might work because it affects the part of the brain tied to feeling reward

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The Department of Health and Human Services recommends at least 150 minutes of moderate intensity aerobic activity weekly, or 75 minutes of vigorous intensity activity

Additionally, new or worsening constipation accompanied by unexplained weight loss (beyond expected therapeutic weight reduction), persistent changes in stool caliber, or alternating constipation and diarrhea warrants evaluation to exclude structural or neoplastic causes, particularly in patients age 45 or older or those with family history of colorectal cancer

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