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RSL3 induces DNA damage, inhibits DNA repair, and promotes autophagy in PTC cells We showed that the RSL3-mediated GPX4 inhibition induced multi-fold rise in intracellular ROS in PTC cells in vitro

This was 25 plus years ago, right

Cancer 89, 589596

Front Microbiol 14:1259133

AICART: aminoimidazolecarboxamide ribonucleotide transferase BHMT: betaine-homocysteine methyltransferase CBS: cystathionine -synthase CTGL: -cystathionase DHFR: dihydrofolate reductase DMGD: dimethylglycine dehydrogenase DNMT: DNA-methyltransferase FTD: 10-formyltetrahydrofolate dehydrogenase FTS: 10-formyltetrahydrofolate synthase GCS: -glutamylcysteine synthetase GDC: glycine decarboxylase (glycine cleavage system) GNMT: glycine N-methyltransferase GPX: glutathione peroxidase GR: glutathione reductase GS: glutathione synthetase MAT-I: methionine adenosyl transferase I MAT-III: methionine adenosyl transferase III MS: methionine synthase MTCH: 5,10-methenyltetrahydrofolate cyclohydrolase MTD: 5,10-methylenetetrahydrofolate dehydrogenase MTHFR: 5,10-methylenetetrahydrofolate reductase NE: non-enzymatic conversion PGT: Phosphoribosyl glycinamidetransformalase SAAH: S-adenosylhomocysteine hydrolase SDH: sarcosine dehydrogenase SHMT: serinehydroxymethyltransferase TS: thymidylate synthase Metabolites