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These medications carry a boxed warning about thyroid C-cell tumors (contraindicated with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings about potential risks including pancreatitis, gallbladder disease, acute kidney injury with dehydration, and worsening diabetic retinopathy with rapid glucose reduction (particularly with semaglutide)

PLoS ONE 11 , e164640 (2016)

Wegovy is FDA approved for weight loss in adults and children 12 years and older with obesity and adults who are overweight

For example, meta-tyrosine and ortho-tyrosine form by hydroxylation of phenylalanine

Washington, D.C.: National Academies Press