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Food and Drug Administration in 2005

It has a well-understood mechanism with a growing body of long-term safety data

Insulin resistance & prediabetes, National Institute of Diabetes and Digestive and Kidney Diseases (2025) Efficacy and safety of once-weekly semaglutide 2.4 mg versus placebo in people with obesity and prediabetes (STEP 10): a randomised, double-blind, placebo-controlled, multicentre phase 3 trial, The Lancet Diabetes & Endocrinology (2024) With prediabetes, action is the best medicine, American Diabetes Association Prevention or Delay of Diabetes and Associated Comorbidities: Standards of Care in Diabetes2025, Diabetes Care (2025) About the Lifestyle Change Program, CDC (2024)

doi: 10.3389/FDDSV.2022.1043617 237 TigasSTsatsoulisA

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