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Giobbie-Hurder A, Gelber RD, and Regan MM (2013) Challenges of guarantee-time bias J Clin Oncol 31 (23) 29632969 PMID: 23835712 PMCID: 3732313 75

Myocardial glutathione depletion impairs recovery of isolated blood-perfused hearts after global ischaemia

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[19] Diagnosis [edit] Graves' disease may present clinically with one or more of these characteristic signs: [20] [21] Tachychardia Goiter Tremor Exophthalmos (protuberance of one or both eyes), periorbital edema Fatigue, weight loss with increased appetite in young people and poor appetite in the elderly, and other symptoms of hyperthyroidism/thyrotoxicosis Heat intolerance Tremulousness Palpitations Two signs are truly diagnostic of Grave's disease (i.e., not seen in other hyperthyroid conditions): exophthalmos and non-pitting edema (pretibial myxedema)