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Published Phase 3 weight-loss results for retatrutide exceed those reported for tirzepatide (22.5% in SURMOUNT-1) and semaglutide (14.9% in STEP-1) at comparable timepoints [1][2][9]

Myostatin inhibitorscomprising direct agents such as monoclonal antibodies and small molecules, as well as indirect modulators including follistatin-based strategies and other pathway regulatorshave demonstrated encouraging results in preclinical and early clinical studies by increasing muscle mass and improving muscle function

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