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Among the issues related to the properties of the compounds, their solubility in aqueous buffers and DMSO is a major concern

They may also enhance the effects of blood pressure medications, requiring dose adjustments under medical supervision

To determine their supposed roles in cardiac glycoside biosynthesis in milkweed, these genes of interest will be targets for silencing using Agrobacterium -mediated transformation harboring RNAi constructs containing our gene(s) of interest

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immediate labs if new medications are added or symptoms develop If ALT/AST rise above 2x upper limit of normal: Hold both agents, investigate, and reintroduce one at a time after normalization This schedule is conservative