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Lipid overload has been suggested to cause the loss or downregulation of autophagy, leading to fat accumulation, mitochondrial disorders, inflammation, and decreased pancreatic -cell quality, all of which may eventually lead to IR and T2DM 30

Monitor for hypoglycemia symptoms, particularly if taking concurrent insulin or sulfonylureas

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These emerging clinical trials strongly suggest that the mitochondrial support provided by carnitine is not just theoretical