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Dehydration worsens constipation (already a common semaglutide side effect), increases fatigue, and can mimic hunger when you are actually just thirsty

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Generalized skin symptoms that may warrant attention include widespread itching (pruritus) without visible rash, development of hives (urticaria), or unexplained rashes

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For example, in a study where obese volunteers had unlimited access ( ad libitum ) to three meals (lunch, dinner and snacks), it was observed that treatment with semaglutide (1 mg/wk) caused a 24% decrease in energy intake during the day, leading to a reduction in body weight of approximately 5 kg after 12 weeks of treatment