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Per FY2026 ICD-10-CM Official Guidelines, the 6th character for complications is required when documented

Common Side Effects When side effects occurred, they were typically mild, transient, and similar in frequency to placebo groups: Reported Adverse Effects Most Common (occurring in small percentage of participants): Mild to moderate headaches (most frequently reported, often resolving with continued use) Injection site reactions (minor redness, swelling, or irritation at injection site) Gastrointestinal effects (particularly at higher oral doses: mild nausea, diarrhea, flatulence) Fatigue (reported occasionally during initial adaptation period) Rare Events: One case of chest tightness was deemed possibly related to treatment in safety trials

Conclusions: Cere treatment was well tolerated and resulted in significant improvements in the global score two months after the end of active treatment

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Kisspeptin offers a fundamentally different and potentially complementary mechanism targeting the hypothalamic dysfunction at the root of PMOS-related anovulation with early human data supporting its relevance