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These symptoms typically emerge during dose escalation and often diminish over several weeks as physiological adaptation occurs
Overall, sulfur-containing amino acid metabolism can be more appropriately viewed as an integrated module of methylation potential and redox homeostasis: the Met-SAM axis is mainly associated with the plasticity of epigenetic and transcriptional programs, the Cys-GSH/H 2 S axis primarily influences oxidative stress and the threshold of inflammatory signaling, and Tau is further linked to antioxidation and the regulation of mitochondrial homeostasis
Cyclodextrins can protect the body from these adverse reactions by selectively delivering drugs to the tumor site, thus reducing systemic toxicity
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meanwhile, avoiding damage to blood vessels, nerves and connective tissue
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