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Exposure to PS-MPs has been shown to induce oxidative stress in murine testicular tissue, resulting in reduced sperm quality and quantity as well as decreased testosterone levels [16]

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The selective action of dutasteride (a 5-reductase inhibitor) in motor neurons, by reducing significantly the formation of the active androgen 5-dihydrotestosterone, resulted in a slowdown of the progression of SBMA and illustrated that active androgen depleting therapies can be promising in the treatment of SBMA (89)