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In order to be very sure of preventing irreversible neurologic damage in vitamin B 12 -deficient individuals, the Food and Nutrition Board of the US National Academy of Medicine advises that all adults limit their intake of folic acid (supplements and fortification) to 1,000 g (1 mg) daily ( Table 3 )

Jankovic J, Goodman I, Safirstein B, Marmon TK, Schenk DB, Koller M, Zago W, Ness DK, Griffith SG, Grundman M, Soto J, Ostrowitzki S, Boess FG, Martin-Facklam M, Quinn JF, Isaacson SH, Omidvar O, Ellenbogen A, Kinney GG (2018) Safety and Tolerability of Multiple Ascending Doses of PRX002/RG7935, an Anti--Synuclein Monoclonal Antibody, in Patients With Parkinson Disease: A Randomized Clinical Trial

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Compounded preparations used in research have shown over 94% stability at 60 days when properly formulated and stored, which supports consistent dosing over typical use periods

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