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In this context, the aim of the present document is to summarize, in the form of a narrative literature review, the currently available data on the main mechanisms of action of GIP/GLP-1 co-agonists and the clinical effects of tirzepatide evaluated in various clinical trials

Figure 1 2.2 Fundamental concepts and molecular mechanisms of ferroptosis Ferroptosis was first described by Dixon in 2012 as an iron-dependent form of cell death featuring uncontrolled lipid peroxidation