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Freeze-thaw cycles may negatively affect certain peptides, so storage conditions should always follow available stability information for the specific compound
For example, should CMS impose upon a hospital a CMP for failing to make public an MRF as required by 180.40(a), even if it did have a shoppable services file or internet price estimator tool as required by 180.40(b), such hospital would not be eligible for a reduction to its CMP by waiving its appeal rights (and the same would pertain were a hospital to have an MRF as required by 180.40(a), but not a shoppable services file or internet price estimator tool as required by 180.40(b))