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It delivers a high dose of the vitamin directly into the bloodstream, bypassing the gastrointestinal tract

The hypermethylation of the promoter region of KEAP1 gene has been identified in cancer cells generated in lung (Wang et al., 2008a

Previous preclinical studies showed that in paclitaxel-induced CIPN models, oral melatonin pretreatment significantly reduced paclitaxel-induced mechanical allergic reactions in male and female animals by decreasing paclitaxel-induced 8-isoprostane F2 levels and C-fiber activity-dependent slowing (ADS) in peripheral nerves, and importantly, melatonin cotreatment with breast or ovarian cancer cells alleviated mitochondrial damage without affecting paclitaxel cytotoxicity [44]

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