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"I had never taken shortcuts in my career and always worked really hard

2016 Nov;96:4857

BajajJSFaganAGavisEASterlingRKGallagherMLLeeHet al

This combination matters because it integrates three complementary pathways that address the central mechanisms of resistant obesity and suboptimal body composition: appetite and satiety regulation, increased energy expenditure and lipid oxidation, and sustained vitality during prolonged caloric deficit

The PIONEER 4 trial showed that oral semaglutide was noninferior to liraglutide (another GLP-1 receptor agonist) for HbA1c reduction but superior for weight loss, and superior to placebo for both outcomes