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Through NRF2-driven GSH synthesis, tumor cells are protected from oxidative stress, which contributes to chemotherapy resistance by reducing the cytotoxic effects of ROS generated during treatment

1.9.1 Role of the gut neuroendocrine system in appetite regulation Several neural, hormonal and psychological factors control the complex process known as appetite

Kleinendorst L, Massink MPG, Cooiman MI, et al

First, effective contraception is essential during treatment with GLP-1 receptor agonists

Individuals with obesity and type 2 diabetes have higher baseline rates of depression and mental health conditions compared with the general population, making it difficult to determine whether reported symptoms represent medication effects or underlying psychiatric comorbidity