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Some case reports and clinical observations suggest that GLP-1 medications might help people with lipedema through weight loss, improved metabolism, and reduced inflammation

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James McKoy, MD Rheumatologist (former) Kaiser Permanente Moanalua Medical Center Moanalua, Hawaii OnabotulinumtoxinA (Botox, Botox Cosmetic) Botox - Cervical dystonia, severe primary axillary hyperhidrosis, strabismus, blepharospasm, neurogenic detrusor overactivity, chronic migraine, upper limb spasticity Botox Cosmetic - Moderate to severe glabellar lines, moderate to severe lateral canthal lines, known as crows feet AbobotulinumtoxinA (Dysport) - Upper and lower limb spasticity, cervical dystonia, and moderate-to-severe glabellar lines in adults

Notably, the enzyme has been linked to obesity and type 2 diabetes (T2D)

Collagen peptides have the most data, with modest effects on knee osteoarthritis symptoms