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Other promising players in the oral obesity space include Viking Therapeutics, which is advancing the GLP-1/GIP agonist VK2735, and Structure Therapeutics, which is running a md-stage study of its selective GLP-1 drug GSBR-1290.

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The addition of glucagon receptor agonism introduces a third axis: increased energy expenditure, enhanced hepatic fat oxidation, and PCSK9-mediated reduction in LDL cholesterol

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Therefore, targeting GPX4 may be a potential therapeutic strategy for PPO