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( B ) Quantification of glycolysis, glycolytic capacity, and glycolytic reserves in caSMCs pretreated with 100 nM GLP-1(2836) or scrambled control for 20 minutes

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Furthermore, we also show neuroprotection and motor improvement in an in vivo mouse model of neurodegeneration 18

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Beyond GLP-1/GIP dual agonism, triple-hormone receptor agonists such as retatrutide further expand this framework by engaging GIP, GLP-1, and glucagon receptors within a single molecule ( In parallel, amylin-based co-agonist strategies, exemplified by the long-acting amylin analogue cagrilintide and its combination with semaglutide, introduce an additional satiety-related signalling axis ( 8.6 Limitations of the current evidence base Several limitations of the current evidence base should be acknowledged