457 Activation of N-methyl-D-aspartate (NMDA) receptors amplifies and prolongs spinal dorsal horn neuron responses, further contributing to pain perception
BIO Jens Juul Holst (Copenhagen, Denmark, 1945) received an MSc in Medical Sciences from the University of Copenhagen, where he went on to earn a PhD in the same subject in 1978
What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology
Some patients benefit from a registered dietitian consultation during this transition to ensure they're meeting prenatal nutritional benchmarks before conception
This process allows fat cells to release stored fatty acids, glycerol, and water, which are then naturally eliminated through the lymphatic system without harming surrounding tissue
