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Since inactive T4 is converted to the active thyroid hormone T3 in the liver, a sluggish liver is also one of the main causes of thyroid dysfunction

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Oxidative Imbalance and Reduced GR Function Several specific scenarios create conditions where hydrogen water's mechanism may provide advantages over relying solely on GR-mediated glutathione recycling: NADPH deficiency states : Conditions that compromise NADPH production, such as glucose-6-phosphate dehydrogenase deficiency, metformin therapy, or severe caloric restriction, limit GR function due to insufficient cofactor availability

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Let's continue to focus on the evidence