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Interestingly, the STEP-8 study 22 revealed a higher incidence of psychiatric events with liraglutide 3 mg (15.0%) compared to semaglutide 2.4 mg (5.6%) and placebo (10.6%)

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If the answer is targeted visceral fat reduction and aggressive body recomposition and you're comfortable with a higher-intensity protocol tesamorelin is the more precise tool for that job

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Whether this carries clinical significance requires longer-term cardiovascular outcome data that is not yet available