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Semaglutide carries a Boxed Warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
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Reports of Biochemistry & Molecular Biology , 10(2), 164172
Nevertheless, the mechanism accounting for this impaired Nrf2 response in diseased liver still needs more exploration
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