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doi: 10.1210/jc.2011-3456
What has changed is the emergence of a pharmacological response to this specific problem
Each weekly injection delivers two active drugs: Semaglutide 2.4 mg a GLP-1 receptor agonist
[26] showed that liraglutide-dependent weight loss relies on its binding to GLP-1Rs located mainly in POMC/CART (cocaine- and amphetamine-regulated transcript) anorexigenic neurons in the ARC, but an indirect inhibitory effect of agouti-related peptide (AgRP) orexigenic neurons via -aminobutyric acid (GABA)-ergic signaling was also observed
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