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The molecular compound nitric oxide aids in transmitting signals to the cells allowing for intercellular communication
Aldose Reductase Inhibitors Aldose reductase inhibitors (ARI) work by blocking the enzyme aldose reductase in the polyol pathway, which under hyperglycemic conditions converts excess glucose into sorbitol, a sugar alcohol that accumulates in nerves and causes osmotic stress, oxidative damage and impaired nerve function [116]
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Dietary interventions emphasizing reduced caloric intake, Mediterranean diet patterns, and avoidance of fructose-sweetened beverages form the cornerstone of management
It can be very beneficial especially for individuals who regularly use aspirin and other drugs which impose a damaging effect on the lining of the stomach and GI tract
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