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With consistent strength training and adequate protein (1.0 to 1.2 grams per kilogram of body weight daily), lean mass preservation improves significantly

Understanding the expected timeline for semaglutide effects helps set realistic expectations and prevents premature discontinuation due to perceived treatment failure

The STEP 1 trial, published in the New England Journal of Medicine in 2021, showed that participants taking semaglutide 2.4 mg weekly lost an average of 14.9% of their body weight over 68 weeks, compared to 2.4% in the placebo group

8, Pharmacology and Therapeutics, August 2022, pp

Weight changes: Do not expect dramatic weight loss in the first month at 2.5mg