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Advantages of secretagogues in research: a more physiological hormonal profile, activation of the complete axis (GH + IGF-1 + IGFBP-3), and intact negative feedback that limits supraphysiological effects

Subsequent cytokine release from necrotic cells amplifies renal inflammation, potentially triggering acute kidney injury and accelerating CaOx crystal retention

Similar findings were observed in murine colitis models (Mizoguchi et al., 1996

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