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human evidence is largely topical and injectable use is unproven
Studies in rats exposed to circadian-disrupting xenobiotics showed Epithalon prevented disturbances in diurnal dopamine rhythms in the median eminence and normalized norepinephrine dynamics in the medial preoptic area
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This creates a critical metabolic dependency, and GLS1 inhibitors such as BPTES or CB-839 have been shown to selectively induce lethal acidification in a broad spectrum of SnCs 72,73 (Fig