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doi: 10.1016/j.coph.2007.04.005 96 LiQLiaoJChenWZhangKLiHMaFet al

Consistently, regardless of the initial positions of palmitate either located in the membrane as seen in the cryo-EM structure or placed outside of the membrane, our MD simulations found that the -carboxylate spacer stably inserted into the TM1-TM2 cleft and the 16-carbon palmitic chain is deeply buried in the receptor-lipid interface, contributing multiple strong contacts to stabilize the complexes (Supplementary Fig

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In various stress-driven conditions, this catabolic process assists in maintaining cellular homeostasis by recycling no-longer-functional cellular components to sustain protein synthesis and metabolism

GOED, which is Global Organization for EPA and DHA