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DSIP use has also been associated with improved stress tolerance and better performance during wakefulness

Murata, G

Villanueva-Peacarrillo ML, Puente J, Redondo A, Clemente F, Valverde I

Abbreviations CVD: Cardiovascular disease T2D: Type 2 diabetes CV: Cardiovascular HF: Heart failure GLP-1RA: Glucagon-like peptide 1 receptor agonist SGLT-2: Sodium-glucose cotransporter 2 MACE: Major cardiovascular events MI: Myocardial infarction ADA: American Diabetes Association HFrEF: Heart failure with reduced ejection fraction HFpEF: Heart failure with preserved ejection fraction FDA: Food and Drug Administration NHANES: National Health and Nutrition Examination Survey CKD: Chronic kidney disease References Grundy SM, Benjamin IJ, Burke GL, et al

Moreover, a pilot study in 19 healthy adults suggested that the bioavailability of R, S -lipoic acid and R -lipoic acid may vary with age and gender (13)