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The fact that 75% of smokers do not develop COPD points to strong defense mechanisms to handle the increased oxidant burden that smoking puts on the lung

Understanding this distinction helps explain why tirzepatide produces greater weight loss in head-to-head comparisons

Still, gastrointestinal issues like vomiting or diarrhea may lead to severe dehydration, which acutely stresses the kidneys

Indeed, TMPRSS2 also caused a loss of the surface FLAG tag in cells transfected with PAR2-WT, but, remarkably, not with PAR2-G37I (Figure 2B)