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One systematic review and network meta-analysis of thirteen studies, published in Springer, evaluated three administration routes of vitamin B12: oral, intramuscular, and sublingual routes

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After treatment with BN for 3 months, BMI, fasting blood glucose, glycosylated hemoglobin, visceral and subcutaneous fat, silk protein E1, leptin, C-reactive protein (CRP), and tumor necrosis factor decreased significantly