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If so, when was it due

and industrial and agricultural compounds like pesticides and nitrates

Rett syndrome, caused by MECP2 gene mutations, disrupts GABAergic interneuron development, lowering GABA concentrations in the hippocampus and prefrontal cortex, leading to developmental regression, such as loss of language and motor skills, and stereotypic hand movements like hand-wringing (77)

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SELENON deficiency is associated with various congenital myopathies, and these patients have impaired glucose metabolism with defective insulin-dependent glucose uptake, which in turn may lead to insulin resistance [88, 89]