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10.1186/1471-2202-7-49 138 ZhangZ.BaiH.MaX.ShenM.LiR.QiuD.et al (2021)

This causes transepidermal water loss (TEWL) to spike

Cagrilintide improves stability and pharmacokinetics of native amylin, extending the elimination half-life to approximately 168192 hours (roughly 7 days) in pharmacokinetic studies, which supports administration via a once-weekly injection protocol in clinical trial designs

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Others split them across the week so the amylin compound and the triple agonist do not stack their strongest hours on top of each other