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Through 13 C 5 -glutamine labeling experiments, they found that these prostate cancer cells also exhibited a greater reliance on glutamine following exosome uptake, with increased levels of 1 3 C-labeled m + 5 -KG and m + 5 glutamate indicative of reductive glutamine metabolism for anaplerosis into the TCA cycle

Circulation Research , 124 (7), 10251044

Under external oxidative stress, the level of Fe 2+ escalates, significantly heightening the sensitivity of melanocytes to ferroptosis (177)

In a follow-up study, the same group demonstrated that HPDL deficiency induces a lethal form of mitochondrial encephalopathy and, importantly, supplementation with HPDL-derived intermediates (4-HMA or 4-HB) was sufficient to alleviate disease symptoms

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