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This pathway differs from the PKC-ROS axis triggered by pharmacological activators such as phorbol 12-myristate 13-acetate (PMA) [53, 54]

These mechanisms are powerful

For example, in a study of almost 17,000 people published in JAMA Ophthalmology in 2024, researchers found an increased risk of NAION among individuals prescribed semaglutide relative to those prescribed other medications to treat type-2 diabetes and obesity

however, gender- and age-specific responses, as well as concurrent medication use (eg, metformin), might influence outcomes

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