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What they found: Favorable safety profile , no serious adverse events at doses up to 100 g/kg Preliminary efficacy signals positive The program stopped before Phase 3 for unknown commercial reasons (the program passed through several sponsor rotations and no one ultimately carried it through) Why it matters: These are the only published clinical data in humans that we have

Get answers to frequently asked questions about tretinoin use

A greater reliance on fat for energy can result in a sparing of muscle glycogen, an enhancement of exercise performance, and a reduction in stored body fat

275 , F79F87 (1998)

Keep the vial standing upright and handle it gently to prevent agitation