Role of DNA methylation is still unclear One of the earliest proposed roles for DNA methylation was the restriction of developmental potentials and prevention of de-differentiation of terminally differentiated cells (Hochedlinger and Plath, 2009)
10.1016/j.biopha.2021.112139 9 FaragA.ElfadadnyA.MandourA
Supports lean muscle maintenance*
Pierno S, Camerino GM, Cannone M, Liantonio A, De Bellis M, Digennaro C, Gramegna G, De Luca A, Germinario E, Danieli-Betto D, Betto R, Dobrowolny G, Rizzuto E, Musaro A, Desaphy JF, Camerino DC (2014) Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice
For example, reduced regenerative capacity and altered immune function in older adults could influence both the efficacy and safety of GLP-1R agonists in managing cancer outcomes