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Preclinical Research Is Not Clinical Proof Animal and laboratory studies can help researchers form hypotheses, examine biological pathways and decide whether further investigation is justified

Circulation 101(3):329335 Chen B, Guo J, Ye H, Wang X, Feng Y (2024) Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling

It is hypothesized that CBZ limits the firing of action potentials by binding to sodium-operated channels, leading to a decrease in the stimulatory effects on neurons 13

In animal clinical studies, semaglutide has caused thyroid tumors