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95% CI, 3.94 to 0.71)

The key transcription factors that regulate gene expression are NF-E2-related factor 2 (Nrf2) via the antioxidant response element (ARE), AP-1, and nuclear factor kappa B (NF-B)

N Engl J Med 379:226235 McGann PT, Ware RE (2015) Hydroxyurea therapy for sickle cell anemia

The dysregulation of some angiogenic factors, such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor- (TGF), and basic fibroblast growth factor (bFGF), may be partially responsible for ovulation and aberrant cysts in PCOS (263)