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Lowering the body temperature to 32 to 33C (89.6 to 91.4F) using cooling blankets decreases intracranial pressure and cerebral blood flow and improves the cerebral perfusion pressure

The proposed direct vascular mechanisms, supported by preclinical and clinical data, include the following: Endothelial protection: GLP-1 receptor agonists promote nitric oxide production, vasodilation, and angiogenesis while inhibiting oxidative stress in vascular endothelial cells Plaque stabilization: Reduced matrix metalloproteinase activity prevents fibrous cap degradation

The EHBD injury was visible at 2 weeks of age and progressed over time, quantified by duct score as described in the Methods section

Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG

Examples of off-label uses include (Pile, 2021