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Combination treatment is not required for every patient and should be individualized

1 GLP-1-RA have been shown to be very effective in reducing A1C in diabetic patients and have demonstrated significant weight loss benefits

A systematic review covering topical, oral and IV glutathione concluded that although topical/oral forms show some effect, the quality of evidence is modest and the effects modest too

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There is a a randomized, placebo-controlled trial, showing TVB-2640, a fatty acid synthase inhibitor, can significantly reduce excessive hepatic fat production, reduce insulin resistance, inflammation and reactive oxygen species production, and improve liver fibrosis in a dose-dependent manner (NCT03938246)