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In doing so, the glutathione molecule itself becomes a reactive thiyl radical, which quickly pairs with another oxidized glutathione molecule to form glutathione disulfide (GSSG)

Ferroptosis is defined by iron-dependent lipid peroxidation, impaired GPX4 activity, and an expansion of the labile iron pool

GR ist ein allgegenwrtiges dimerisches Flavoprotein mit 100 bis 120 kDa, das die Reduktion von oxidiertem Glutathion (GSSG) zu reduziertem Glutathion katalysiert, wobei Beta-Nicotinamidadenindinucleotidphosphat (NADPH) als Wasserstoffspender verwendet wird