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Under the action of acetyl coenzyme A synthetase long chain family member 4 (ACSL4), PUFAs bind to CoA and are esterified and inserted into the cell membrane by lysophosphatidylcholine acyltransferase 3 (LPCAT3)

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As well, SIRT1 activation protects DNs from the neurotoxic effect of MPTP by augmentation of mitochondrial biogenesis (Al-Kuraishy et al

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