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The randomized and double-blinded study compared the effect of weekly semaglutide 2.4 mg plus IBT against placebo plus IBT over 68 weeks

Although this insulin-deficient model primarily resembles type 1 diabetes mellitus (T1DM-like), it provides a robust and widely accepted platform to investigate diabetes-associated central nervous system alterations, particularly hyperglycaemia-driven neuroinflammation and cognitive impairment

KDM6A loss triggers an epigenetic switch that disrupts urothelial differentiation and drives cell proliferation in bladder cancer

Therefore, leucine represents the BCAA with the most compelling mechanistic and clinical evidence relevant to musclevascular interactions and healthy aging, justifying its emphasis in the present review

10.1016/S0014-5793(98)01000-X